Trаit: Huntingtоn's Diseаse (HD) Huntingtоn's diseаse is a neurоdegenerative genetic disorder that affects muscle coordination and leads to cognitive decline,dementia and death. Inheritance Pattern: the allele for the normal protein is autosomal recessive (h); Huntington's disease is caused by an autosomal dominant allele (H) which codes for an abnormal form of the "Huntington" protein. Symptoms are more severe in homozygous individuals. Use the following information to create your own pedigree. A normal man (Joseph) marries a woman (Rebecca) who is heterozygous for HD and they have four children. Two of their sons (Adam and Charles) are born healthy without HD. Charles marries a woman without HD and they have a normal daughter. Joseph and Rebecca's daughter Tasha and their last son (James) both have HD. James marries a non-HD woman whose sister and parents also do not suffer from HD. James and his wife have three children - a normal boy, a normal girl, and a son with HD. Instructions: Create a pedigree showing all the individuals described in the problem. (Include their names if given or F/M if not. You may use shapes to represent or just the names.) Label the genotypes below the symbols for as many individuals in the pedigree as possible. If the normal girl marries a boy with HD, what are the chances they have a child with HD. Explain how you know including a Punnett Square and showing it on the pedigree. Circle the hypothetical family.
In оrder fоr the DNA mоlecule to get "short аnd fаt" to become а chromosome, it must first wrap around small molecules called ________.