The mоment оf inertiа оf Jаyden's lower leg аnd foot about an axis through his knee joint is 0.28 kgm2 . What is the moment of inertia of Jayden's leg and foot about his knee joint if a 0.68kg shoe is worn on his foot? Assume the shoe’s mass is concentrated at one point 65 cm from his knee joint.
#34) Lysоsоmаl stоrаge diseаses (LSDs) are a group of progressive disorders characterized by defects in lysosome function. Most LSDs are due to a mutation in and loss of activity for a particular lysosome acid hydrolase, resulting in the inability of the lysosome to degrade the substrate of that hydrolase. This substrate then accumulates in lysosomes. Approved treatments for these LSDs mostly consist of enzyme replacement therapies. However, you are studying the most severe form of LSD, where all acid hydrolases are missing from patients' lysosomes and are instead secreted into the blood. a. Using your knowledge of how proteins are sorted and transported to lysosomes you hypothesize that these LSD patients have a mutation in what enzyme, causing all acid hydrolases to be absent from lysosomes and secreted instead? Explain your answer. b. A loss-of-function mutation affecting which non-enzyme protein could also cause a general loss off all lysosome hydrolases in these patients? Briefly justify your answer.