SIADH — Syndrоme оf Inаpprоpriаte Antidiuretic Hormone Secretion (Study Outline) For study only—this is not medicаl advice or a substitute for professional care. 1. Background Definition:SIADH is characterized by excess ADH secretion → water retention, dilutional hyponatremia, and concentrated urine, occurring despite normal volume status and normal renal function. Pathophysiology: Excess ADH → ↑ renal water reabsorption → ↓ serum osmolality → hyponatremia. Body responds with natriuresis to maintain near-normal volume → euvolemic hyponatremia. Urine becomes inappropriately concentrated relative to serum. Etiology: CNS disorders: stroke, hemorrhage, trauma, infections, tumors. Pulmonary diseases: pneumonia, tuberculosis, small-cell lung cancer (ectopic ADH). Medications: SSRIs, carbamazepine, cyclophosphamide, oxytocin, NSAIDs. Malignancy: especially small-cell lung carcinoma (classic exam clue). Postoperative state: transient ADH secretion. Idiopathic in older adults. Epidemiology: Common cause of euvolemic hyponatremia, especially in hospitalized patients. 2. History Symptoms depend on severity and rate of sodium drop: Mild/moderate hyponatremia: nausea, headache, lethargy, confusion. Severe/acute hyponatremia: vomiting, somnolence, seizures, coma. Chronic SIADH: subtle cognitive changes, gait instability, falls. Historical clues: Recent CNS event or lung disease. Use of SSRIs, carbamazepine, or antipsychotics. Known or suspected small-cell lung cancer. 3. Exam Findings Volume status: EUVOLEMIC (key exam point). No edema No dry mucous membranes Normal skin turgor Neurologic: variable confusion, agitation, seizures if severe. Respiratory: findings related to underlying lung disease if present. General: normal BP and HR unless comorbidity present. 4. Making the Diagnosis Characteristic Laboratory Pattern: Measure SIADH Finding Serum sodium ↓ hyponatremia Serum osmolality ↓ (100 mOsm/kg) Urine sodium ↑ (>40 mEq/L) Volume status Euvolemic BUN/creatinine Low-normal Uric acid Low Diagnostic Steps: Confirm hypotonic hyponatremia (low serum Na and low serum osmolality). Assess volume status → euvolemia suggests SIADH. Check urine studies: concentrated urine + high urine sodium. Exclude other causes: Hypothyroidism (TSH) Adrenal insufficiency (cortisol/ACTH) Renal failure Gold Standard: Euvolemic hypotonic hyponatremia with inappropriately concentrated urine in absence of adrenal, thyroid, renal disease, or diuretics. 5. Management (Exam Concepts) (Conceptual overview only—no dosing or treatment regimens.) 1. Treat Underlying Cause Stop causative medication (SSRI, carbamazepine). Treat lung infection or remove tumor if possible. 2. Fluid Management Fluid restriction = cornerstone for chronic SIADH. Salt tablets or increased dietary solute may help raise sodium. Hypertonic saline used in severe symptomatic hyponatremia (conceptual). 3. Medications (Conceptual) ADH antagonists (vaptans) for resistant cases. Loop diuretics with salt supplementation to enhance free water clearance. 4. Monitoring Avoid overly rapid sodium correction to prevent osmotic demyelination syndrome (exam favorite). Frequent monitoring of serum sodium. QUESTION A 72-year-old man is admitted to the hospital with worsening confusion and lethargy over the past two days. He has a history of chronic obstructive pulmonary disease (COPD) and was recently diagnosed with small cell lung cancer. He takes inhaled bronchodilators and has no history of diuretic use. On examination, he appears euvolemic. There is no peripheral edema or signs of dehydration. Laboratory results are as follows: Serum sodium: 122 mEq/L (135–145) Serum osmolality: 258 mOsm/kg (275–295) Urine sodium: 48 mEq/L Urine osmolality: 620 mOsm/kg BUN: 6 mg/dL (7–20) Creatinine: 0.7 mg/dL (0.6–1.3) Which of the following is the most appropriate initial treatment? A) Hypertonic (3%) saline infusionB) Fluid restrictionC) Intravenous normal salineD) Oral sodium chloride tablets
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