A pathologist examines four epithelial biopsy specimens:…
A pathologist examines four epithelial biopsy specimens: Specimen Histologic Findings A Poorly-differentiated cells with high atypia and tripolar mitoses; cells penetrate beyond the basement membrane into the subjacent soft tissue B Marked pleomorphism, hyperchromatic nuclei, numerous atypical mitoses, complete loss of polarity, scant basement membrane extension C Moderately differentiated cells with only mild pleomorphism, but cells that don’t penetrate the basement membrane D Poorly differentiated cells with marked pleomorphism and extensive necrosis, but with only a few cells entering the basement membrane Which specimen carries the LEAST risk for metastasis at the time of biopsy?
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