Mrs. HW (female, 83 years old) is struggling to sleep following admission to a new care home and the staff have asked for a ‘sleeping tablet’ to be prescribed.   Which is the LEAST APPROPRIATE course of action?

Mr. GA (male, 58 years old) presents to the GP with a 3-week history of breast tenderness and fluid coming from his nipples. He has a past medical history of schizophrenia and his current medication includes sulpiride.   What drug-related side-effect is Mr. GA MOST LIKELY to be suffering from?

Mrs. LG (female, 29 years old) has contacted her midwife because since having her baby 4 weeks ago, she has been tearful most of the time, is struggling to sleep and feels that she isn’t bonding well with her baby.   Which of the following is the MOST APPROPRIATE next step in management for the midwife?

Miss LQ (female, 24 years old) has a diagnosis of autism spectrum disorder (ASD) and is undergoing her annual review with the GP.   Which characteristic is MOST LIKELY to be present in Miss LQ?

Mrs. LP (female, 41 years old) requires treatment for depression. When looking through her past medical records you notice that she has previously taken an overdose of antidepressants. Which antidepressant is LEAST APPROPRIATE to prescribe?

Mr. JP (male, 60 years old) has a history of depression and has been prescribed phenelzine 15mg three times a day for the past 4 weeks. He is doing well with his mood and reports feeling much better. This evening, after a meal of mature cheddar cheese and a glass of red wine, Mr. JP suddenly experiences a severe headache, rapid heartbeat, and nausea. He is concerned and calls 111. What is the most likely cause of Mr. JP’s symptoms?

Mr. BW (male, 37 years old) has a past medical history of bipolar disorder and has been stable on valproate semisodium (valproic acid) 1g twice a day for 3 years. He has been admitted to hospital and diagnosed with severe bipolar depression. His psychiatrist deems it appropriate to prescribe lamotrigine in addition and asks you to advise on the starting dose for Mr. BW.   What initial dose would you advise?

A researcher performs a statistical test and obtains a p-value of 0.73. What does this most likely suggest about the observed effect?

_______________ is a value for a test for significance for association between expected result vs. actual result.

A researcher wants to compare the average blood pressure between two independent groups: one taking a new medication and one taking a placebo. Which statistical test is most appropriate for determining whether the means are significantly different?