Assume you’re researching Drug Y, which binds to the same Gα…
Assume you’re researching Drug Y, which binds to the same Gαi-coupled receptor as Drug X. You determine that Drug Y is a partial agonist of this GPCR. What do you expect to observe if you apply Drug Y to cells expressing this receptor? (Assume no other drugs are present in your experiment.)
Read DetailsPaclitaxel is derived from Taxus baccata, a type of evergree…
Paclitaxel is derived from Taxus baccata, a type of evergreen tree. In Phase 2 and Phase 3 clinical trials, patients treated with paclitaxel showed reduced time to progression and significantly longer survival time compared to standard therapy. This drug was subsequently FDA approved to treat some forms of ovarian cancer and other solid tumors. Paclitaxel for injection is available in 30 mg, 100 mg, or 300 mg multi-dose vials. These vials contain 6 mg/mL paclitaxel suspended in a mixture of polyoxyethylated castor oil and dehydrated ethanol, which is diluted with saline prior to intravenous infusion. Based on this information, the indication of this drug is: , and the formulation of this drug is: .
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