The relatively long half-life of lipid-soluble hormones (ste…
The relatively long half-life of lipid-soluble hormones (steroid hormones) compared to water-soluble hormones is due in part to the way that these hormones are passed into the filtrate from the glomerular capillaries. Lipid-soluble (steroid) hormones have a relatively long half-life due to their relatively small size, which allows them to easily pass back into the peritubular capillaries if released into the filtrate.
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