A pathologist examines four epithelial biopsy specimens:…
A pathologist examines four epithelial biopsy specimens: Specimen Histologic Findings A Well-differentiated cells with minimal atypia and rare mitoses; basement membrane intact B Marked pleomorphism, hyperchromatic nuclei, numerous atypical mitoses, complete loss of polarity, basement membrane intact C Moderately differentiated cells with only mild pleomorphism, but small nests of cells penetrate through the basement membrane into the underlying connective tissue D Poorly differentiated cells with marked pleomorphism and extensive necrosis, but the lesion remains confined above an intact basement membrane Which specimen carries the greatest risk for metastasis at the time of biopsy?
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