Using the information below, complete the citation in AMA style: January 2021 J Trace Elem Med Biol Pages 70-84 Volume 20 doi: 10.1016/j.jtemb.2015.05.006 Issue 6 Nutritional Determinants of Macular Pigment  Herrera Juan, Lima Jean, Medeiros Alejandro, Figueiredo Hank, Andrade Raul, Ururahy Maria, Rezende Anton, Brandão-Neto Jorge, Almeida Miguel

a. Is the abstract below an example of primary or secondary research? b. If primary identify the research design utilized and if secondary, identify the type of article (literature review, systematic review, or meta-analysis)  c. Explain WHY you chose the type of article/type of research identified in part b. ________________________________________________________________ Lutein, a carotenoid, exhibits various biological activities such as maintaining the health of the eye, skin, heart, and bone. Recently, we found that lutein has dual roles in suppressing bone resorption and promoting bone formation.  Osteoclast differentiation was assessed by coculturing primary osteoblasts and bone marrow cells or culturing an osteoclast precursor cell line.  Osteoclast differentiation was significantly inhibited by lutein, astaxanthin, and β-cryptoxanthin. In contrast, only lutein promoted osteoblastic calcified bone nodule formation. To elucidate the molecular role of lutein, we functionally analyzed the NF-κB complex, a molecule involved in bone metabolism, especially in osteoclasts. Docking simulations showed that lutein binds to IKK, thus inhibiting the activation of NF-κB. In a cell culture analysis, the phosphorylation of p65, the active form of NF-κB in osteoblasts, was suppressed by lutein treatment. In vivo, a μCT analysis of the bone microarchitecture showed that lutein improves several bone parameters while maintaining bone mass. Lutein is effective in maintaining bone mass by controlling both bone resorption and formation, which is applied to prevent disuse-induced osteoporosis.

a. Is the abstract below an example of a primary of secondary publication? If secondary, what type and how do you know? If primary, what is the research design? Explain why you identified that particular research design. b. Are there any significant results? Which ones and how do you know? (can just list the numbers and explain) c. Are there any highly significant results? Which ones and how do you know? (can just list the numbers and explain) ____________________________________________________________ Although artificial and non-nutritive sweeteners are widely used and generally recognized as safe by the US and European Union regulatory agencies, recent studies report that fasting plasma levels of erythritol, a commonly used sweetener, are associated with heightened incident cardiovascular disease risks. Effects of dietary erythritol on thrombosis phenotypes in humans have not been examined. We tested the impact of erythritol or glucose consumption on multiple indices of stimulus-dependent platelet responsiveness in healthy volunteers (n=10 per group). Participants ingested either 30 grams of erythritol or glucose in a beverage.  Dietary erythritol (30 g), but not glucose (30 g), lead to a >1000-fold increase in erythritol plasma concentration (P

Explain the major difference between a systematic review and a meta-analysis.

Read the abstract below, then select the BEST option to describe this publication. ________________________________________________ In the last two decades, India has witnessed a dramatic rise in the consumption of packaged foods, especially among adolescents. Food labelling is often recognised as an instrumental population-based approach which can enable consumers to make informed food choices by providing all the necessary details about the food product on the packaging. In the Indian context, where adolescent obesity and the ensuing non-communicable diseases are escalating, it is crucial to understand adolescents’ views on the use of non-nutritious packaged foods and food labels. Therefore, our aim was to explore Indian adolescents’ perceptions regarding the consumption of packaged food and use of food labels. Convenience sampling was employed to recruit 29 boys and 15 girls (aged 10-19 years) from rural Varanasi, India. Semi-structured, face-to-face interviews were conducted in the local language. Interview recordings were transcribed verbatim and translated to English. The adolescents reported frequent consumption of packaged food like potato chips, biscuits, chocolates, deep-fried Indian snacks both at school and home. Packaged foods were regarded as tasty, safe, and fresh. Brand name, date of expiry and cost were often read by the study respondents. Nevertheless, they reported difficulty in understanding other components of the label (e.g., nutrition information) and they were not aware of the negative impact of consuming unhealthy packaged foods. Nearly all the respondents insisted that food labels should be written in the local language for easy understanding. These emerging findings underscore the need to design school-based food literacy programs for vulnerable Indian adolescents to address obesity and diet-related complications in early adulthood. 

The nurse educator is educating a group of nursing students on Hepatitis B. Which of the following is true of Hepatitis B? Select all that apply.

Statistical significance is objective and quantifiable whereas clinical significance is subjective and not quantifiable.

I have read the HonorLock information in the ‘content’ area of the course and will reach out in advance if I have any questions.

The nurse working in an HIV prevention clinic is preparing to discuss PrEP with patients. Which of the following patients should not be started on PrEP?

Literature reviews and systematic reviews are both secondary publications, but literature reviews are covering one primary research article, while systematic reviews look at multiple primary research articles.