CASE 1: (There are 2 questions on this case). A newborn foa…
CASE 1: (There are 2 questions on this case). A newborn foal develops respiratory distress, lacticacidemia (increased blood lactate) and acidosis. A heart murmur is noted and tests reveal hypertrophic cardiomyopathy (dilated heart). Tests show increased glycolytic and TCA cycle enzyme levels. Mitochondria were isolated from the heart and tested in the lab using either pyruvate (generates primarily NADH) or succinate (generates FADH) as a substrate. With pyruvate oxygen consumption and ATP production were low. With succinate, both oxygen consumption and ATP production were normal. CASE 1, Q1: Which of the following are true?
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