A 50-year-old woman presents with joint pain, swelling, and…
A 50-year-old woman presents with joint pain, swelling, and morning stiffness lasting more than an hour. She has tenderness and synovitis in multiple joints, including the wrists and small joints of the hands. Laboratory tests reveal positive rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies. Her erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are elevated. Radiographs show early erosive changes in the metacarpophalangeal joints. Which of the following is the most appropriate initial pharmacological treatment for this patient?
Read DetailsA 58-year-old female undergoing chemotherapy for breast canc…
A 58-year-old female undergoing chemotherapy for breast cancer develops severe nausea and vomiting. She is prescribed ondansetron. Two hours after administration, she develops palpitations and lightheadedness. ECG reveals a prolonged QT interval. Which of the following best explains the mechanism responsible for this adverse effect?
Read DetailsMark is a 55 year old man who presents with a sudden onset o…
Mark is a 55 year old man who presents with a sudden onset of severe pain and swelling in his right big toe. Upon examination, he is diagnosed with acute gouty arthritis. Mark has a history of hypercholesteremia and takes atorvastatin (Lipitor) 20 mg daily. Considering Mark’s comorbidity of hypercholesteremia, which of the following medications used for acute gouty arthritis treatment should be avoided due to potential interactions?
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