Consider the following reaction at equilibrium: N2O4 (g) ↔ 2…
Consider the following reaction at equilibrium: N2O4 (g) ↔ 2NO2 (g). What is the equilibrium constant in concentration (Kc) of the forward reaction if the concentration of N2O4 is 0.124 M and the concentration of NO2 is 0.0258 M?
Read DetailsLabel each of the following changes as: i) a synonymous mut…
Label each of the following changes as: i) a synonymous mutation, ii) a non-synonymous substitution, iii) a stop-loss mutation, iv) a nonsense (stop-gain) mutation. (A genetic code table is below). A) UGA –> UCA B) UAC –> UAA C) AGA –> AAA D) AGA –> CGA
Read DetailsColorblind 1 Your next project is to genetically map the loc…
Colorblind 1 Your next project is to genetically map the locus for color blindness, an X-linked recessive trait, with respect to simple sequence repeat (SSR) markers. Like many X-linked recessive traits, colorblindness is usually found in males. However, the mutant allele frequency is sufficiently high that colorblind females do occur. In this problem, + is the allele that leads to normal vision, and clr is the allele associated with color-blindness. Assume complete penetrance and no new mutations. The family below has been genotyped for two SSR markers – there are 2 alleles for SSR 72 (Z&W) and 3 alleles for SSR 73 (a,b, & c). The mother is deceased; thus, her DNA has not been analyzed. Below the pedigree are the results from the DNA analysis – the heavier bands indicate more DNA. A) What is the (deceased) mother’s genotype at SSR72? B) What is the (deceased) mother’s genotype at SSR73? C) What is the most likely phase relationship between the alleles at SSR72 and the color blindness locus in the mother. D) What is the most likely phase relationship between the alleles at SSR73 and the color blindness locus in the mother.
Read DetailsA certain X-linked dominant disease in humans occurs when th…
A certain X-linked dominant disease in humans occurs when there are more than 40 repeats of a CGG trinucleotide in a particular gene. 5′ CAGTATGCA——(CGG)n——-ATGCGTAAT 3′ 3′ GTCATACGT——(GCC)n——-TACGCATTA 5′ Where n refers to the number of CGG repeats. In the lab freezer, you find PCR primers that are complementary to the sequence on either side of the repeats, which will allow you to amplify DNA fragments containing the repeat. Shown below are the outline of a pedigree for the disease described above, and a representation of a gel showing PCR-amplified fragments detecting the number of CGG repeats in 8 siblings. The DNA corresponding to each individual is directly below his or her place in the pedigree. Which individuals are male? Which individuals are female? Which individuals are affected?
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