Please define PI3K in the following ways:a. As an enzymatic…
Please define PI3K in the following ways:a. As an enzymatic activity, mentioning the substrate and product.b. Molecular components.c. As a target of what kind(s) of oncogenic driver events?d. As a target of genomic driver events in specific cancers – Name 2 cancers for up to 2 total points, 1 point for each cancer accurately named.
Read DetailsQuestion 1: Mechanotransduction and the Tumor Microenvironme…
Question 1: Mechanotransduction and the Tumor Microenvironment Part A: Define “cellular mechanotransduction” and list three distinct examples of physical forces or mechanical signals that cancer cells may encounter in the physiological environment. Part B: In the context of the “Physical World” interacting with cell biology, explain how the extracellular matrix (ECM) changes during tumorigenesis compared to normal tissue. Part C: Describe the “feed-forward” loop described in the lecture regarding ECM stiffening. How does increased tissue tension affect cancer cell phenotype?
Read DetailsThink about everything that you have learned over the course…
Think about everything that you have learned over the course of the semester in this class. Identify three concepts that you believe will benefit your career. Why and how do you think these concepts will help you? Explain your thoughts in detail.
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