Author Archives: Anonymous
There are SIX questions from which you are required to answe…
There are SIX questions from which you are required to answer only THREE; any additional answers will not be marked. All questions are weighted equally, and worth a maximum of 100% each. There are 3 answer boxes below this box. Each answer box MUST be used to answer one of the questions you select. Please also remember to tell us which question you are answering. See the example below: ‘This is my answer to Question 1…’ Questions are as followed: — Question 1 (answer both parts of this question): a) Describe the basic structure and function of an enzyme. (20%) b) Many therapeutic drugs are inhibitors of enzyme activity. Explain the different types of reversible enzyme inhibition and briefly describe an experimental approach to determine the mechanism of enzyme inhibition for a compound. (80%) — Question 2 (answer both parts of this question): Haematopoiesis occurs in the bone marrow of adults. a) Explain the general process of haematopoiesis, including the main cell types produced. (40%) b) Select a single blood cell lineage (not platelets) and describe the process of cell production as well as the functional role of those cells. (60%) — Question 3: Describe the information that is obtained from a blood film and full blood count and explain how this can be used to aid patient diagnosis (include in your answer examples of pathological causes of abnormal results). (100%) — Question 4 (answer all parts of this question): CASE STUDY – A 40-year-old woman complained of lethargy, nausea, and right abdominal pain. On further questioning, she reported a 6-month history of an acute pain stabbing on the right side, and that her urine is quite a dark yellow. Results from a blood sample are as follows: a) Describe the process of bilirubin metabolism and excretion and evaluate whether assessment of bilirubin is a useful liver function test. (40%) b) Suggest a possible diagnosis for this patient. Include an explanation of the underlying pathology to justify your diagnosis, as well as how this translates to the lab findings. (60%) — Question 5 (answer all parts of this question): Describe the following tests used in the transfusion laboratory. Include in your answer the underlying principle of the test as well as the clinical applications. a) Direct agglutination (DA) (40%) b) Direct antiglobulin test (DAT) (30%) c) Indirect antiglobulin test (IAT) (30%) — Question 6: Describe the antigens and antibodies in the ABO and Rh blood group systems and discuss their clinical significance. (100%)
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