You are studying a newly described receptor called GPR100. Y…
You are studying a newly described receptor called GPR100. Your collaborators have circumstantial physiological data in mice suggesting that this receptor can activate PLCb (leading to Ca++ release from intracellular stores) and can also activate ERK-MAP. You have screened for ligands that bind to GPR100 and found two molecules that binds to the receptor and you termed them UC2024 and UC2025. You know nothing about how UC2024 and UC2025 may affect GPR100 signaling. Design experiments to determine if UC2024 and UC2025 function as an agonist, antagonist, or inverse agonist and also design experiments to determine if these ligands are biased in any way?
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