Which of the following is not classed as an in vitro test?

Which of the following statements best describes the efficacy of a drug?

ADRENERICS… Consider the structures shown here for the questions below: *** a)  Define the term AGONIST: [blank1] *** b) Define the term ANTAGONIST: [blank2]  *** c) Drug (ii) is called albuterol and is used to treat the respiratory disease known as asthma. Albuterol is an agonist that binds in a similar manner compared to an endogenous neurotransmitter, compound (i.). Name compound (i.) [blank3] *** d)  Drug (iii) is called propranolol and it is an antagonist compared to compound (i.). Briefly describe the pharmacophore common to all three structures (i. ii. and iii.) [blank4] *** e) Briefly, how do the varying structures shown above lead to their agonist or antagonist activity? [blank5] *** f)  Rank the drugs in order from most water soluble to least water soluble: [blank6] Structure (i.) is a “Catecholamine”, where the catechol portion is circled in the figure below. It undergoes metabolism to an inactive compound. *** g) Provide a generic name for an enzyme that could complete this metabolic reaction. [blank7]

Which of the following statements best describes the affinity of a drug?

RULE OF 3s and 5s… Consider the antihistamine drugs Loratadine (Claritin®) and Desloratadine (Clarinex®). Recall Lipinski’s Rule of 5 and answer the following questions… *** a) Does DESLORATADINE meet the requirements for hydrogen bond donor capability?   How many HBD groups are present? [blank1]       *** b) Does DESLORATADINE meet the requirement for hydrogen bond acceptor capability? How many HBA groups are present? [blank2]         *** c) Is the in vivo metabolic conversion of loratadine to desloratadine a Phase I or II rxn? [blank3] *** d) Using the “RULE OF 3s”, complete the table below to predict whether the logP values for the drug DESLORATADINE would be less than, greater than, or equal to 0.     Carbon# =  [blank4] Water# = [blank5] Log P   [blank6]  0  

Given the following log P values, what is the predicted log P value for the disubstituted structure?  

logP questions

From July through December, Community Hospital had 32 patients with complications and 2,394 discharges.  Calculate the complication rate.  Round to two decimal places. 

An HIM manager must determine the number of FTEs needed to code 950 discharges per week. It takes 20 minutes to code each record. Each coding professional works 37.5 productive hours per week. How many FTEs will the HIM manager need? Round to one decimal place.

What is the calculation formula for Gross Mortality Rate?