BCH4024 F25 E2 Q17: Cholera is a common disorder found in countries without proper sanitation. Cholera is caused by a bacterial toxin that constitutively (without ligand interactions) activates a G protein associated with a G protein-coupled receptor. Which of the following would NOT be observed in a patient with cholera?
Read DetailsBCH4024 F25 E2 Q42: Inorganic fluoride inhibits enolase. In an anaerobic experimental system that is metabolizing glucose as a substrate, which of the following compounds would you expect to increase in concentration following the addition of inorganic fluoride?
Read DetailsBCH4024 F25 E2 Q44: A 7 month-old baby presented with poor sucking ability and loss of head control and motor skills. He had poor appetite, vomited frequently, cried continuously, and had frequent seizures. Genetic analyses revealed a mutation in his mitochondrial DNA, inhibiting various mitochondrial processes. Which mechanism(s) may be inhibited by mutations in mitochondrial DNA? PDH Complex activity Electron transport Oxidative phosphorylation Glycogen synthesis Glycogen breakdown
Read DetailsBCH4024 F25 E2 Q16: Botulinum toxin is a neurotoxin that causes paralysis of the muscles. This is accomplished by cleavage of SNARE proteins contained within the presynaptic compartment of the neuron. What role do SNARE proteins play in neurotransmitter release at the synapse?
Read DetailsBCH4024 F25 E2 Q31: You perform an experiment with three preparations of intact mitochondria, Prep1, Prep 2, and Prep 3. You treat the preparations as follows: Prep 1 Add succinate Prep 2 Add succinate and dinitrophenol Prep 3 Add succinate and oligomycin What would you expect to happen to the proton gradient and ATP synthesis in Prep 2?
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