A nurse is reviewing a client’s prescription for 1,000 mL of 5% dextrose in water IV to infuse over 8 hr. At 1400, the nurse observes that there is 250 mL of solution remaining in the client’s current IV bag. At what time should the nurse hang the next bag of IV solution? ___________ military time (Just write the numbers)

A nurse is caring for a client who has a deep vein thrombosis and is prescribed heparin by continuous IV infusion at 1,400 units/hr. Available is heparin 25,000 units in 250 mL D5W. The nurse should set the IV pump to deliver how many mL/hr? (Round the answer to the nearest whole number)  ___________________ mL/hr

Lipid soluble drugs, such as heroin or THC, readily enter the brain, because:

After drug administration has occurred, the amount of drug in the blood that is free to bind at specific target sites is/are referred to as

Actor Dwayne Johnson (also known as ‘The Rock’) has been taking Prozac (fluoxetine), a selective serotonin reuptake inhibitor, for his depression for some time now. However, he has found that the drug has become less effective over time. This effect may be due to serotonin receptor_____________ produced by the drug.

A 35-year-old woman underwent multiple surgeries after a car accident. Her surgeon prescribed 10 mg of Vicodin (acetaminophen+ hydrocodone) taken daily for her postoperative pain. The treatment provided adequate analgesia (pain relief). The accident led to a recurrence of her major depressive disorder, for which she renewed her use of anti-depressant fluoxetine (Prozac) at 20 mg/day. She was unaware that hydrocodone is an inactive prodrug and the substrate for CYP450-2D6 enzyme that transforms it to hydromorphone – an active form of this drug and the actual analgesic. She was also unaware that Fluoxetine is a strong CYP450-2D6 inhibitor. As result of this drug interaction she experienced:

Prolonged administration of a drug often requires to increase its dose to obtain the same effect. This is due to a well-known phenomenon called:

In the dose–response curve, a decrease in potency is indicated by a shift

During the process of behavioral drug tolerance, after repeated, frequent use of a drug in the same environment:

The nurse clarifies that the immune system failure theory states that: