A patient has been taking fluoxetine but needs to switch to an MAOI (phenelzine).What is the minimum washout period required before starting the MAOI?

A 70-year-old patient with depression is started on citalopram. Which monitoring concern is most important at higher doses in older adults?

A 55-year-old patient with depression and controlled hypertension is started on an SNRI. At follow-up, their blood pressure has increased. Which medication is the most likely cause?

A 40-year-old patient with depression discontinues sertraline due to sexual dysfunction and requests an alternative with minimal sexual side effects. Which medication is the best option?

A 50-year-old patient with MDD is prescribed venlafaxine. They ask how this medication differs from SSRIs. What is the best explanation?

A 32-year-old woman with a history of major depressive disorder is started on escitalopram 10 mg daily. Three weeks later, she presents with decreased need for sleep (4 hours/night yet feels rested), increased energy, rapid speech, irritability, and impulsive online shopping spending over $3,000. She reports her mood is “amazing” and she has “never felt better.”

A 28-year-old patient with major depressive disorder (MDD) reports persistent low mood and anhedonia. You prescribe an SSRI. Two weeks later, the patient asks how the medication is helping their brain function. Which explanation is most accurate?

A 17-year-old girl started fluoxetine 2 weeks ago for depression. Her mood is slightly better, but she now reports passive suicidal thoughts without a plan or intent.  

A 33-year-old patient with depression and obesity is concerned about weight gain with antidepressants. Which medication would be the most appropriate to minimize weight gain and potentially promote weight loss?

A provider is considering starting bupropion for depression given its favorable side effect profile regarding sexual dysfunction and weight gain.Which patient has an absolute contraindication to bupropion?