_____ involves successive rearrangement at the light-chain loci when reactivity to self-antigen occurs during B-cell development.

During maturation of T and B cells, which of the following enzymes do you expect to see?

What cells would be able to express an MHC presenting a peptide that is 13-25 amino acids in length?

From what we talked about in class, a child born with SCID is lacking which of the following?

TCR molecules and BCR’s both have (complimentary determining regions) CDR’s/HV’s (hypervariable regions).

Antigenic proteins from extracellular pathogens are internalized by an endosome (phagosome), which then forms a phagolysosome and degrades the proteins to produce peptides.

Apart from centrocytes, what other cells would you expect to find in the light zone of the germinal centers?

Antigenic proteins from extracellular pathogens are internalized by an endosome (phagosome), which then forms a phagolysosome and degrades the proteins to produce peptides.

Somatic recombination for T-cells takes place in the_________.

In general, when is the expression of genes RAG 1 and RAG 2 halted during the development of a B-cell?