Match the following antihypertensive drugs to their key adverse effects. Each answer may be used more than once, or not at all. (5)

A patient on long-term warfarin therapy for atrial fibrillation presents with a markedly elevated international normalised ratio and active bleeding. Which agent is most appropriate for urgent reversal of anticoagulation? (1)

The following drugs is contraindicated to a pregnant woman diagnosed with hyperthyroidism: (1)

A 68-year-old man with chronic heart failure presents with worsening dyspnoea and bilateral basal crepitations. Which drug class provides rapid symptomatic relief by reducing preload but does not improve long-term survival? (1)

A patient with an acute ischaemic stroke presents 6 hours after symptom onset. Computed tomography scan excludes haemorrhage. What is the most appropriate immediate antithrombotic therapy? (1)

A 64-year-old man with ST-elevation myocardial infarction (STEMI) presents to a district hospital without access to percutaneous coronary intervention (PCI). Thrombolytic therapy is planned. Which mechanism best explains the action of alteplase? (1)

Match the following drugs to their primary pharmacological actions. Each answer may be used more than once, or not at all. (5)

60-year-old man with stable heart failure with reduced ejection fraction (HFrEF) is initiated on dapagliflozin despite having no history of diabetes. What best explains the benefit of this drug in heart failure? (1)

Sildenafil is associated with (1)

Mr. KL presents at the Accident and Emergency Department with a painful erection of the penis that has lasted for more than four hours (priapism). After aspiration of engorged blood from the penis, he should be treated with penile injections of. (1)