There two parts to this question, please read carefully and answer each part.    Below is a segment of the original DNA TEMPLATE strand and one that has sustained a mutation.  ORIGINAL DNA Template Strand:  3′ –  CCC CTA ATT  – 5′ MUTATED DNA Template Strand:  3′ –  CCC CTT ATT  – 5′ 1. Using the framework of the central dogma, trace the path of this error from the nucleus to the final phenotype (outward expression of the gene).   Be sure to use the following terms in your answer: transcription, mRNA, codon, translation, amino acid, and protein function.  (6 points) 2. A classmate claims, “All point mutations result in disease or a change in phenotype.” Is this statement true or false? Provide an explanation for your answer.  (2 points)

Use the diagram of the IGF2/ H19 locus below to answer the questions below. a. [1] IGF2 at location E is… b. [2] Site(s) that serves as an enhancer for the H19 gene that is ON. c. [3] Site that is methylated. d. [4] H19 at location G is… 

Problem Management Plus (PM+) can be characterized as a mental health intervention that:

Scenario: A humanitarian NGO is designing a mental health program for survivors of a recent natural disaster. They plan to use a socio-ecological model to guide the intervention. Question: Briefly describe what a socio-ecological approach means for this program and give one example of an intervention activity at two different levels (for example, individual and community).

Scenario: You have an evidence-based group therapy manual originally developed in Europe to treat depression, and you want to use it with adolescents in a very different cultural setting after a crisis. Question: What are two key cultural adaptations you would consider making to this intervention to ensure it is appropriate and effective for the new context?

According to the Inter-Agency Standing Committee (IASC) Guidelines on MHPSS in Emergency Settings, which of the following is NOT a core principle for mental health and psychosocial support programs?

What is a common challenge when using standard Western-developed mental health assessment tools (e.g., questionnaires) in a different cultural or humanitarian context?

Which is the major nerve of the perineum?

Label left subclavian vein

Label corpus callosum