Serotonin–dopamine antagonists (SDAs) reduce extrapyramidal symptoms because 5HT2A antagonism increases dopamine release in the nigrostriatal pathway.

A CYP450 inhibitor will typically cause what change in substrate drug levels?

Neurotransmitters exert their effects primarily at the:

Which amino acid is the precursor to serotonin (5‑HT)?

Which clinical effects are most strongly associated with dopamine blockade in the nigrostriatal pathway? (Select all that apply.)

Glutamate is the brain’s primary:

Atypical (second‑generation) antipsychotics are considered “atypical” primarily because they have relatively higher 5‑HT2A antagonism than D2 antagonism, rather than being pure D2 blockers.

Continuous 100% occupancy of dopamine D2 receptors is necessary to achieve antipsychotic efficacy.True or False?

 In Stahl’s integrated model, dopamine hyperactivity in schizophrenia occurs primarily in:

Antagonism at histamine H1 and serotonin 5‑HT2C receptors is thought to contribute to weight gain and metabolic changes with some atypical antipsychotics.