A 22-year-old male patient weighing 72kg is receiving treatm…
A 22-year-old male patient weighing 72kg is receiving treatment in hospital for a severe exacerbation of asthma. Aminophylline has been prescribed and the respiratory registrar would now like to begin twice daily theophylline, aiming for a steady state plasma concentration of 10mg/L. The patient has an estimated theophylline clearance of 4L/h. You calculate theophylline steady state plasma concentration using the following formula: Css = (S x F x D) / (Cl x T) Css = steady statement concentration (mg/L) S = salt factor = 1 F = bioavailability = 1 D = dose (mg) Cl = clearance (L/hour) T = dosing interval (hours) The hospital dispensary has Uniphyllin (theophylline) available in 200mg, 300mg and 400mg strengths. How many milligrams of theophylline should be prescribed to this patient every 12 hours?
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