Of the following, the disease most closely associated with granulocyte hyposegmentation is: 

A 56-year-old female with a history of multiple blood transfusions is being monitored for iron overload. Her CBC shows mild anemia. A peripheral smear stained with Prussian blue reveals small, blue-purple inclusions near the periphery of red blood cells. Question:What are the inclusions in the red blood cells, and what do they represent?

Multipotent stem cells are capable of producing: 

What is the MCH if the Hct is 20%, the RBC is 2/4 x 10^6/uL (2.4 x 10^12/L) and the Hgb is 5g/dL (50 g/L) 

All of the findings listed below may be seen in acquired hemolytic anemias of the autoimmune variety. The one considered to be the most characteristic is: 

Which of the following bone marrow findings favor the diagnosis of multiple myeloma?

The majority of the iron in an adult is found as a constituent of: 

CBC: Hgb: 8.2 g/dL Hct: 25.0% MCV: 90 fL WBC: 65.0 x10⁹/L Platelets: 45 x10⁹/L Patient Summary:A 45-year-old male presents with fatigue, bleeding gums, and frequent bruising. He notes a recent 10-pound weight loss and intermittent fevers. Physical exam reveals petechiae and mild hepatosplenomegaly. Peripheral smear shows large immature cells with high nuclear-to-cytoplasmic ratio and fine chromatin. Some of the blasts contain rod-like inclusions. Microscopy Image: Cytochemical Stain Recommendation: Myeloperoxidase (MPO) stain: Positive Sudan Black B: Also positive What is the most likely diagnosis? 

Patient Summary:A 72-year-old male presents with mild fatigue, night sweats, and painless swelling in his neck and groin. He reports a gradual decline in energy over several months. Physical exam reveals non-tender cervical and axillary lymphadenopathy. Peripheral smear shows many small, mature-appearing lymphocytes and frequent smudge cells. Microscopy Image: Cytochemical Stain Recommendation: Tartrate-resistant acid phosphatase (TRAP) stain: Negative  What is the most likely diagnosis?

In order for hemoglobin to combine reversibly with oxygen, the iron must be: