Which transporter pumps drugs out of cells and contributes to drug resistance in cancer?

What effect does high plasma protein binding have on drug distribution?

Which factor decreases drug distribution?

Which property increases a drug’s ability to cross the blood-brain barrier (BBB)?

A patient with cirrhosis and hypoalbuminemia is given a drug that is normally highly protein-bound. What happens?

Mr. Hale, 66, is admitted for dizziness and poor oral intake after a viral illness. Home meds: lisinopril 10 mg daily, atorvastatin 20 mg nightly, aspirin 81 mg. On arrival: BP 128/74, HR 78, RR 18, SpO₂ 98% RA, afebrile. Labs pending. Two hours later he reports palpitations and mild shortness of breath. BP 112/68, HR variable 120–140, RR 22, SpO₂ 96% RA. Answers in complete sentences: Identify Rhythm Strip 1 and Rhythm Strip 2. Explain the key ECG features that led you to each identification. Based on the current presentation (strip 2), is the patient stable or unstable? Justify using clinical data. List your first three nursing priorities for Rhythm Strip 2 in this patient.

During which phase of clinical trials are large populations studied to confirm effectiveness and safety compared to current treatments before FDA approval?  

Volume of distribution (Vd) is defined as:

A patient is brought into the emergency department via EMS after an episode of near-syncope at home. On arrival the patient is pale and diaphoretic, complaining of lightheadedness and chest pressure. Vitals: BP 78/46 mm Hg, HR 32/min, RR 22/min, SpO2 95% on room air.  Answer in complete sentences: Using the strip and your assessment findings, classify the rhythm category and explain the underlying pathophysiology. Identify the top reversible etiologies you would prioritize ruling in or out and why. Detail your immediate nursing and medical management for the first 4 minutes, then the next phase of care. State whether defibrillation is indicated and justify your reasoning. Predict patient outcomes when a reversible cause is identified and treated promptly versus when no cause is found or treatment is delayed; support with physiologic reasoning.

Which property allows drugs like fentanyl to be administered transdermally?