A 70-year-old with dementia develops agitation. Which prescribing principle is MOST appropriate?

A 45-year-old man treated with high-potency typical antipsychotics develops rigidity, hyperthermia, autonomic instability, and elevated CK. What is the MOST likely diagnosis?

A 28-year-old woman on quetiapine for bipolar disorder complains of excessive daytime sedation and weight gain. She has no psychotic symptoms. Which antipsychotic is MOST appropriate as an alternative with lower sedation and metabolic risk?

A patient taking lithium reports nausea, diarrhea, and a coarse tremor. Which finding most strongly suggests lithium toxicity?

A pharmacogenomic test reveals a patient is a poor CYP2D6 metabolizer. He is taking a TCA. What is the MOST likely clinical implication?

A patient abruptly discontinues long-term clonazepam use. Which withdrawal symptom is most concerning?

A patient with schizophrenia exhibits prominent positive symptoms. Which dopaminergic pathway is MOST implicated?

A 35-year-old woman presents to the ED with confusion, diaphoresis, hyperreflexia, and clonus. She recently started an MAOI while still taking sertraline. What is the MOST likely diagnosis?

A patient on buprenorphine-naloxone asks why naloxone is included. Which explanation is BEST?

A 10-year-old is started on an extended-release stimulant. Which baseline assessment is MOST appropriate prior to initiating stimulant therapy?