Isocitrate dehydrogenase couples the oxidative decarboxylation of isocitrate to the reduction of NAD+ according to the two half-reactions i s o c i t r a t e → α – k e t o g l u t a r a t e + C O 2 + 2 e – + H + N A D + + H + + 2 e – → N A D H Select the free energy diagram that best describes the energetics of the enzyme-catalyzed electron transfer from isocitrate (iso) to NADH. ICDHcoupledRxn.png  

Given the generalized energy charge curve below, identify the changes in ATP and AMP concentrations and the change in the rate of glycolysis when the energy charge decreases from 0.95 to 0.89 (dashed lines). EnergyCharge3.png

Genomic anticipation refers to observations that a genetic disorder occurs at an earlier age in successive generations, whereas genetic imprinting occurs when gene expression varies depending on parental origin.

A deletions can cause issues due to ____.

This question is part of your extra credit. It will be out of 3 points, but that will not be displayed in Canvas for this question. I will enter it manually to allow for it to be extra credit. Detail two examples of how environmental conditions can affect how genotype is expressed as phenotype. You must pick two different environmental conditions and give details provided for each example in lecture.

In chickens, comb shape is determined by genes at two loci (R, r and P, p). A walnut comb is produced when at least one dominant gene R is present at one locus and at least one dominant gene P is present at a second locus (genotype R_ P_). A rose comb is produced when at least one dominant gene is present at the first locus and two recessive genes are present at the second locus (genotype R_ pp). A pea comb is produced when two recessive genes are present at the first locus and at least one dominant gene is present at the second (genotype rr P_). If two recessive genes are present at the first and the second locus (rr pp), a single comb is produced. Give genotypes for comb shape of the parents in the following cross:  Rose crossed with single produces 10 rose and 11 single offspring.

In some flowers a red pigment, cyanidin, is synthesized from a white precursor. The addition of a hydroxyl group to the cyanidin molecule causes it to become purple.  A parental cross between homozygous plants with purple flowers and homozygous plants with white flowers produced an F1 generation with purple flowers.  A cross between two F1 plants produced F2 plants with the following flower colors: 94 purple, 31 red and 43 white.  Provide an explanation for these results.  Include parental, F1 and F2 genotypes and phenotypes. (You do not need to do a chi-square analysis here.) 

What priority education should the nurse provide to a client that has been diagnosed with acute pyelonephritis?

Histone deacetylation will cause chromatin to be more open and therefore not inhibit expression of genes in that region.

Choose the wrong statement in the regulation of imprinting.