A clinical trial is investigating the effectiveness of Erzofri (paliperidone), an extended-release injection for the treatment of schizophrenia. It considered the number of patients experiencing a relapse in symptoms compared to established treatment. The results of the trial are summarised below:     Absolute risk of relapse in the Erzofri group (ARC) Absolute risk of relapse in the control group (ART) Occurrence of recurrent stroke 0.022 0.04   How many patients will need to be treated with Erzofri to prevent one relapse in schizophrenia symptoms? ARC = the absolute risk of events in the control groupART = the absolute risk of events in the treatment groupARR (absolute risk reduction) = ARC – ARTRRR (relative risk reduction) = (ARC – ART) / ARC NNT (number needed to treat) = 1 / ARR

A child who weighs 22kg is prescribed melatonin 0.1%w/v solution at a dose of 10mL ON.   What is the daily dose of melatonin in microgram/kg? Give your answer to the nearest whole number

Describe how a secondary antibody is used in immunological diagnostic tests, and explain why it is important.   (5 points)

A mutation inserts one nucleotide near the beginning of a gene. Predict what effect this will have on the organism. (3 points) How does this compare to a mutation that changes one nucleotide later in the gene, like C to A ? (3 points)

A synchronous generator rated 11 KV,50 MVA has a per unit impedance of 0.2 per unit on its own base,then its impedance referred to 22KV,150 MVA would be

Per unit value for any quantity =

Overreliance on quantitative analysis is ethically problematic because it:

A solar eclipse occurs during a new moon when Earth is directly between the moon and the sun.

The star Sirius A is at a distance of 8.611 LY from Earth. It has an apparent brightness, b equal to 1.16 × 10−7 W/m2 ? What is the power output (luminosity) of Sirius A?  Recall that 1 light-year = 9.5 x1015m.Hint: Apparent brightness b, depends on both luminosity, L,  and distance , d.

What is the most common oral manifestation associated with Celiac disease?