Chronic myelomonocytic leukemia is classified in the WHO system as

An alert medical laboratory scientist should recognize all of the following peripheral blood abnormalities as diagnostic clues of MDS except 

An 11-month-old female presented with her family to her pediatrician with the complaint of failure to thrive. Her personal and family history histories are unremarkable. The patient was underweight and had tachycardia with a faint heart murmur. She also has a cleft lip and palate.   Patient Results Reference Interval WBC 5.8 4.5-11.0 x 10^9/L RBC 1.27 4.3-5. x 10^12/L HGB 3.8 13.5-16.0 g/dL HCT 12.3 39-55% MCV 99.9 80-11 fL MCH 30.1 25.4-34.6 pg MCHC 31.1 31-37 g/dL RDW 21.2 11.5-14.5 % PLT 330 150-400 x 10^9/L The patient’s differential was unremarkable with 24% neutrophils, 74% lymphocytes, and 2% monocytes. The red blood cell morphology shows microcytosis.  What is the differential diagnosis?

What testing would you run to confirm? What are the results?

The treatment that has shown the best success rate in young patients with severe aplastic anemia is

What is a major indication of MDS in the peripheral blood and bone marrow?

A woman visited her physician for a routine pregnancy exam. The patient has no history of anemia or hematologic disorders. The physician ordered a hemoglobin variant screen to ensure there would be no hematologic complications during the pregnancy. The alkaline pH hemoglobin electrophoresis revealed a band in the S location and in the A location. The sickle solubility test is negative. What is the most likely diagnosis for this patient? Why?

A characteristic abnormality of hereditary spherocytosis noted in the CBC is

A 29-year-old woman presented to her primary care physician for a routine medical exam. She brought along her 3-year-old daughter as her husband had to work. The patient’s family history is unremarkable. Her personal history includes the one pregnancy and natural birth that had no complications.    Patient Results Reference Interval WBC 5.9 4.5-11.0 x 10^9/L RBC 4.64 4.3-5. x 10^12/L HGB 11.9 g/dL HCT 36.4 39-55% MCV 78.0 80-11 fL MCH 25.6 25.4-34.6 pg MCHC 32.7 31-37 g/dL RDW 14.3 11.5-14.5 % PLT 1362 150-400 x 10^9/L What is the differential diagnosis?

A 63-year-old female presented to the emergency department with blurred vision in her right eye and weakness in her right hand. The patient has a history of deep vein thrombosis so a CT scan and an MRI were ordered. Both came back negative.    Patient Results Reference Interval WBC 12.3 4.5-11.0 x 10^9/L RBC 7.90 4.3-5. x 10^12/L HGB 15.3 g/dL HCT 56.2 39-55% MCV 65.3 80-11 fL MCH 19.5 25.4-34.6 pg MCHC 29.8 31-37 g/dL RDW 10.1 11.5-14.5 % PLT 549 150-400 x 10^9/L What is the differential diagnosis?