A 52-year-old man with severe alcohol use disorder is interested in medication-assisted treatment after completing inpatient detoxification. He has normal renal function. He expresses strong motivation to remain abstinent but admits that cravings are high when he is around friends who drink. He wants “something that will stop me from drinking if I slip.” Which pharmacologic agent is most appropriate for this treatment goal? 

Which toxicity can occur with prolonged nitroprusside infusion? 

A 29-year-old man with a history of intravenous heroin use is brought to the ED unresponsive with shallow respirations (RR 6/min) and pinpoint pupils. He receives IV naloxone 0.4 mg, and within minutes he becomes alert but develops severe agitation, diaphoresis, piloerection, tachycardia, hypertension, and nausea. Which best explains this clinical presentation? 

A 55-year-old on quinidine develops QT prolongation and torsades de pointes. Which electrolyte abnormality likely contributed? 

A patient on levodopa reports “wearing off” between doses. Which adjustment is appropriate? 

A patient with treatment-resistant schizophrenia is started on clozapine. What is the most important baseline test? 

A patient on chronic benzodiazepine therapy suddenly discontinues the drug. What is the most concerning complication? 

Which neurotransmitter system is central to reward and reinforcement in addiction? 

A 58-year-old man had a heart attack (STEMI) treated with stent placement 3 months ago. He now has frequent premature ventricular contractions (PVCs) on Holter monitoring. He asks if there is a medicine to “stop the extra beats.” Which drug class improves survival in this setting? 

A patient on donepezil develops dizziness and a heart rate of 48 bpm. This is most likely due to: