Two neurons are placed in a bath solution where pre-synaptic…
Two neurons are placed in a bath solution where pre-synaptic neuron 1 (N1) makes an excitatory chemical synapse onto post-synaptic neuron 2 (N2). A stimulating device causes action potentials to develop in N1 (the red spikes are the APs). These APs propagate down the axon of N1 and cause the release of glutamate neurotransmitter from N1 onto N2. The glutamate receptor in this scenario is the ionotropic AMPA receptor which causes an EPSP in N2. The image below shows the membrane potential traces recorded during a control experiment. Which of the following would occur if you accidentally included an antagonist of GABA receptors to the bath solution and then stimulated N1 with the brief positive current using the same electrode? (reminder that agonists of GABA receptors cause IPSPs)
Read DetailsTwo neurons are placed in a bath solution where pre-synaptic…
Two neurons are placed in a bath solution where pre-synaptic neuron 1 (N1) makes an excitatory chemical synapse onto post-synaptic neuron 2 (N2). A stimulating device causes action potentials to develop in N1 (the red spikes are the APs). These APs propagate down the axon of N1 and cause the release of neurotransmitter from N1 onto N2. The neurotransmitter causes EPSPs in N2 that can temporally summate to threshold as shown by the blue data traces. A toxin that blocks the voltage – gated sodium (Na+) channel is then added into the bath solution and N1 is again stimulated with the device. Which of the following statements is INCORRECT about the data traces recorded in the presence of this toxin? (you are looking for the statement that is wrong)
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