Pyrazinamide is associated with the following drug interactions:                                             1.   Decreases hepatic metabolism of warfarin; dosage adjustment is necessary2.   Decreases the effectiveness of oral contraceptives by enhancing their metabolism 3.   Decreases urate clearance, thus dosage adjustment of antigout agents necessary4.   Decreases metabolism of alcohol, concomitant use is best avoided5.   Decreases the blood levels of nevirapine, concurrent use is best avoided

The following drug is associated with haemorrhagic cystitis:              BleomycinMethotrexateCyclophosphamideRituximabVincristine

Resistance to emtricitabine occurs by the following mechanism:               1.   Mutations in the plasmodial cytochrome b gene2.   Mutations on the enzyme catalase-peroxidase3.   Mutations in the viral neuraminidase enzyme 4.   Mutations on the viral reverse transcriptase enzyme5.   Mutations in the fungal glucan synthase enzyme

The following is a therapeutic use of topiramate except:                                                  1.        Generalised tonic-clonic seizures2.        Focal seizures3.        Lennox-Gastaut syndrome4.        Myocardial infarct5.        Prophylaxis for migraines

The following drug is used for the treatment of herpes simplex virus (HSV):        1.        Abacavir2.        Tenofovir3.        Aciclovir4.        Efavirenz5.        Lopinavir

Match the following drugs to their most correct adverse effects. Each answer may be used more than once or not at all.

The following are indications of metronidazole EXCEPT:                                      1.        Amoebiasis2.        Giardiasis3.        Trichomoniasis4.        Fusobacterium5.        Leishmaniasis

Zolpidem:                                                                                                                           1.        Is a sedative agent2.        May be used in the treatment of anorexia3.        It is used for somnolence4.        It is a long-acting benzodiazepine5.        It is used in the treatment of focal seizures

The following are true regarding phenytoin except:                                                          1.        Blocks sodium channels in the nerve membrane2.        Used in the treatment of absence seizures3.        May be used in the treatment of status epilepticus4.        Used in the treatment of tonic-clonic seizures5.        Long term therapy may cause folate deficiency

The following can be used as prophylaxis for headaches except:                      1.        Clonidine2.        Pizotifen3.        Propranolol4.        Ergotamine5.        Flunarizine