Describe the mechanism of action of beta-2 receptor agonists…
Describe the mechanism of action of beta-2 receptor agonists such as albuterol (structure shown) or salmeterol. Identify important structure-activity elements. What happens inside the cell after the agonist binds to the receptor? What kind of amino acid residues are essential in the active center of the target for activity of the beta-2 receptor agonist? Structure of beta-2 receptor agonist albuterol
Read DetailsYou are tasked to evaluate an antibotic drug for its oral bi…
You are tasked to evaluate an antibotic drug for its oral bioavailability. Which physicochemical parameters are important to determine if a drug is feasible for oral administration? List and briefly describe optimal ranges for these parameters. Then evaluate the following structure and the provided information from SwissADME to determine if this structure has beneficial ADME properties for oral administration. Structure of antibiotic drug Physicochemical properties Formula C37H67NO13 Molecular weight 733.93 g/mol Num. heavy atoms 51 Num. arom. heavy atoms 0 Fraction Csp3 0.95 Num. rotatable bonds 7 Num. H-bond acceptors 14 Num. H-bond donors 5 Molar Refractivity 189.36 TPSA 193.91 Ų Log Po/w (XLOGP3) 3.06 Log S (ESOL) -5.86 Solubility 1.02e-03 mg/ml ; 1.39e-06 mol/l Class Moderately soluble P-gp substrate Yes CYP3A4 inhibitor No Provide as much information as possible.
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