In the classical model of a voltage-dependent K+ channel, how many times does a single alpha subunit weave in and out of the membrane (i.e. how many transmembrane domains does it have)?

Which of the following would INHIBIT postsynaptic depolarization following a presynaptic action potential?

Tetraethyl ammonium (TEA) is applied to a neuron to block voltage gated potassium channels. The neuron is then voltage clamped above threshold and CURRENT is recorded. Compared to a recording at the same voltage clamp, but without TEA, which part of the current will change? HINT – think about how current and voltage plotted

In which scenario would the 2P  leak channel pass potassium current?

The probability that a single potassium channel is open is directly proportional to the driving force on the channel.

____________ channels do NOT have an inactivation domain.

For a neuron at rest, if you greatly reduced the permeability of potassium and increased the permeability for sodium, what would you expect as a result? (Select all that apply)

The voltage-gated sodium channel is mutated so that it de-inactivates more quickly than normal. How will the neuron be affected?

You voltage clamp a neuron at +30mV. Select the answer which best describes the driving force on sodium and potassium in this system. (Remember, assume Vrest = -60mV; EK+ = -70 mV; ENa+ = +50mV; T = 19°C; Threshold = -40mV)

If you voltage-clamp a neuron up to +60mV, what type of current(s) will be detected? (select all that apply)