To create estrogens, cells must first create androgen hormones. The aromatase enzyme converts testosterone into 17-b-estradiol, a form of estrogen. Aromatase inhibitors block this reaction, preventing the creation of estrogens that estrogen receptor (ER) positive breast cancers use to promote proliferation. Therefore, aromatase inhibitors are a therapeutic option for ER+ breast cancer.

A Phase I clinical trial involves:

A study is investigating how average income in countries is related to the prevalence of colorectal cancer (CRC). They find that CRC is higher in developed countries than in the poorer ones. We might predict from such findings that being rich may increase your risk of CRC.  However, in industrialized countries, the opposite is the case: poor people have higher CRC rates than rich ones.  This is an example of what?

A community partner expresses concern that past research projects “took data and disappeared.” The research team wants to rebuild trust. Which strategy best demonstrates ethical, trust‑building practice?

Which of the following is the most likely molecular mechanism that causes resistance to the HER2-targeting therapy trastuzumab?

A new small molecule inhibitor targeting progesterone receptor (PR) has been developed and shows efficacy to treat PR+ breast cancers. However, about 25% of patients relapse and their tumor returns despite treatment. Which experimental design would help you determine the molecular mechanism for how the tumor acquired resistance to this new molecule?

Fecal Immunochemical Tests have a sensitivity of 73% to 88% and specificity ranging from 90% to 96% for colorectal cancer (CRC) detection. The test is better at:

Which type of moraine forms as a ridge of sediment along the side of a valley glacier?

Chapter 11 Assets that are expected to be used by the business for more than one year are considered long-term assets; all others are current.

Chapter 9  Bad debts are uncollectible amounts from customer accounts and are  a necessary aspect of allowing customers to use credit to pay for goods and services.  The allowance method estimates bad debt during a period, based on past experience and industry standards.   Using this method, a merchandising company would make what entry every month to recognize, in a timely manner, the estimate for bad debt.   In the space below please write the account to be debited and then the account to be credited when recording the monthly bad debt estimate.