A 50-year-old woman presents to the clinic for a 6-month fol…
A 50-year-old woman presents to the clinic for a 6-month follow-up. Her medical history includes osteoarthritis of multiple joints, major depression, insomnia, alcohol use disorder, diabetes, and chronic obstructive pulmonary disease (COPD). She has a 25-pack-year history of smoking. She does not report new complaints beyond chronic pain, for which she is requesting refills. She takes methadone 10mg TID, cyclobenzaprine 5 mg TID for muscle spasms, and zolpidem 10mg at night as needed for insomnia. A review of the prescription drug monitoring program (PDMP) shows she has no apparent irregularities and fills medications on time. Which of the following risk factors is most likely to increase her risk of accidental overdose?
Read DetailsA 42-year-old man with schizophrenia presents to the clinic…
A 42-year-old man with schizophrenia presents to the clinic for follow-up. He was recently switched from olanzapine to ziprasidone due to excessive weight gain and metabolic side effects. He reports feeling well overall with no worsening of psychiatric symptoms. His medical history is significant for hypertension and hyperlipidemia. He does not use alcohol or illicit drugs. On examination, his vital signs are within normal limits. A 12-lead electrocardiogram (ECG) reveals a QTc interval of 490 ms (normal: < 450 ms). Laboratory results, including serum electrolytes and renal function, are unremarkable. What effect of ziprasidone is responsible for the EKG finding?
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