A 63-year-old male presents with extreme fatigue and feelings of malaise. A complete blood count reveals a white blood cell count of 83,000 x109 /L, marked anemia and thromocytopenia.  A bone marrow aspirate revealed hypercellular marrow with 36% blasts. Immunophenotyping is positive for CD13 and CD33, and negative for CD 19, CD20, CD41 and CD61.  Karyotypic yeilds t(8;21) and RUNX1-RUNX1T1 fusion is detected. What is the most likely disorder?

Neutrophils observed in the differential of a 14 year old boy demonstrate heavy purplish cytoplasmic granulation with the presence of dohle bodies. Chief complaint listed in the EMR is fever. This trait is indicative of

The CBC for a patient shows decreased WBC and RBC values. Abnormal development is noted for a number of cells on the peripheral blood smear. A bone marrow is ordered and provides the following results: Cellularity is decreased, considering the age of the patient Normal M:E ratio Dysplastic changes noted in myelocytic and erythrocytic cell lines.  17% blasts; Auer rods present  

Match the MCV/RDW that would most likely correlate with each clinical scenario.

In a 1 month old with alpha thalassemia, you would expect to find:

Hypersegmentation of neutrophilic nuclei is hallmark of which disorder?

A 25-year-old woman presents with fatigue and pallor. Her laboratory results are as follows: Hemoglobin (Hgb): 8.0 g/dL Hematocrit (Hct): 24% Reticulocyte Count: 5% RBC Count: 2.8 x 10⁶/µL Reticulocyte Maturation Factor: 2.0 (adjusted for anemia, for Hct

Combined with the relative reticulocyte count, which index can provide the greatest insight into activity of the bone marrow during treatment for an anemia? 

You are performing a differential for a patient with absolute leukocytosis and lymphocytosis. The following peripheral blood picture under the microscope should prompt you to do which of the following?

Hypersegmentation of neutrophilic nuclei is hallmark of which disorder?