Hypersegmentation of neutrophilic nuclei is hallmark of which disorder?

Which of the following myeloproliferative disorders is characterized by an elevated white count and a markedly elevated platelet count?

Hemoglobin electrophoresis can be used to detect an abnormal hemoglobin. Findings can be confirmed and more accurately quantitated using which high resolution methodologies? 

A 19-year-old male visits his physician because of a persistent cough and progressive fatigue over the past month. Physical examination reveals prominent lymphadenopathy. Laboratory analysis reveals a WBC count of 20 × 109/L with 23% reactive lymphocytes. Patient serum is positive for heterophile antibody. Based on this information, from what is the patient most likely suffering?

A patient has a WBC count of 250 × 109/L, and a peripheral blood smear contains many granulocytes and granulocytic precursors including 2% blasts. Pending further tests, which of the following neoplastic conditions is the most likely diagnosis?

A 63-year-old male presents with extreme fatigue and feelings of malaise. A complete blood count reveals a white blood cell count of 83,000 x109 /L, marked anemia and thromocytopenia.  A bone marrow aspirate revealed hypercellular marrow with 36% blasts. Immunophenotyping is positive for CD13 and CD33, and negative for CD 19, CD20, CD41 and CD61.  Karyotypic yeilds t(8;21) and RUNX1-RUNX1T1 fusion is detected. What is the most likely disorder?

The CBC of a patient from the clinic patient shows absolute lymphocytosis, sustained 10 weeks duration, with increasing WBC counts.  (peripheral blood image shown below). What is the most likely disorder?

A patient reports to the lab for annual blood work. The CBC shows moderate anemia, which is reported to the physician. Morphologically, the RBCs are of normal size and shape. A reticulocyte count is reflexed and reported to be 0.7%, with a RPI = 1. Which cause of anemia is suggested?

The CBC for a patient shows decreased WBC and RBC values. Abnormal development is noted for a number of cells on the peripheral blood smear. A bone marrow is ordered and provides the following results: Cellularity is decreased, considering the age of the patient Normal M:E ratio Dysplastic changes noted in myelocytic and erythrocytic cell lines.  17% blasts; Auer rods present  

Interpret the following results: WBC count: 102 × 109/LDifferential: 13% segmented neutrophils28% band neutrophils15% metamyelocytes8% myelocytes6% promyelocytes15% lymphocytes8% basophils7% monocytes LAP score: 15 (reference interval:  0–400) What disease is suggested?