Level 2 – SN1, E1, SN2, E2  We’ve covered the essentials for SN1, SN2, and E1 reactions and determining how a set of reaction conditions will proceed involves ranking 3 factors: 1) The nucleophile/base2) The leaving group3) The solvent Focusing on these 3 factors, and recalling what we’ve discussed in the slides, which of the following is true?

When treating a patient with Multiple Sclerosis, a therapist performs the MiniBEST and finds that the patient has significantly impaired anticipatory postural control. Which of the following complaints might the patient report based on these findings?

An electron is moving as a free particle in the -x direction with momentum that has magnitude 4.50 x 10-24 kg m/s.  What is the one-dimensional, time-dependent wave function of the electron?

Photorefractive keratectomy (PRK) is a surgery process that can correct near- and far-sightedness by using a laser to remove part of the lens of the eye to change its curvature and hence focal length. The procedure can remove layers 0.25 m thick using laser pulses lasting 0.012 ps with a beam of wavelength 193 nm. a. (8points) In what part of the electromagnetic spectrum does this laser lie, and what is the energy of each photon? b. (6 points) What is the uncertainty in the energies of the photons?

Select True or False for each of the following statements: In GWAS, most statistically associated variants are causal/functional variants. In other words, most of the time a SNP allele at a statistically significant SNP locus will increase risk for the disease/phenotype being investigated by the GWAS. [false1] With GWAS it is relatively easy to detect risk variants that are rare with a small to moderate effect size using GWAS. [false2] A GWAS has the power to detect variants with very small effect sizes if the sample size is at least two thousand. [false3]

Fill in the blanks with the best answer from the dropdown menu. Use each item from the dropdown menu only once.     In the immune system, the complement cascade tags [pathogens] for [phagocytosis] by [immunecells]. In the brain, the complement system may tag [synapses] for [pruning] by [microglia].

Pretend you are a scientist who has just conducted a GWAS. Your GWAS shows SNP 1 in the image below as the lead SNP associated with a disease. (This would be the SNP with the tallest peak on your Manhattan plot.) SNP 1 is in a non-coding region of the genome, so it’s not clear how a SNP allele at this locus would increase risk for disease. Thus, you look for more information to make a hypothesis about which SNP locus might be the functional/causal SNP (i.e., the locus with a SNP allele that actually increases risk of developing the disease). You have the information below:   Based on the information above, the best hypothesis is that SNP [2] is the functional SNP. (Keep in mind, you will need to do more experiments to provide evidence to support this hypothesis.) From the list provided, which SNP is in linkage equilibrium with SNP 1? [4]

A patient with stage IV cancer reports fatigue interfering with daily routines. Which outcome measure is best to assess this symptom?

Based on the typical postural changes that occur with Alzheimer’s Disease, which of the following intervention sets form the MOST appropriate plan of care?

For individuals with Alzheimer’s Disease and gait deficits, what type of learning strategy is MOST beneficial?