Describe the mechanism of action of local anesthetics such a…
Describe the mechanism of action of local anesthetics such as procaine (structure shown) or lidocaine. Identify important structure-activity elements. Why is the degree of ionization an important physicochemical parameter for the activity of local anesthetics? What kind of amino acid residues are essential in the active center of the target for activity of the local anesthetic to be effective? Structure of local anesthetic procaine
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