EXTRA CREDIT (UP TO 3 POINTS) Please discuss the Statute of…
EXTRA CREDIT (UP TO 3 POINTS) Please discuss the Statute of Frauds. Also, discuss 6 types of contracts covered by the Statute of Frauds and as many exceptions as you can remember from the class discussion. Or discuss something that you learned in this class.
Read DetailsBonus Question The disease EID (Epidemiology Infectious Dise…
Bonus Question The disease EID (Epidemiology Infectious Diseasitis) was first discovered on an online discussion board in the College of Public Health at UF on 8/1/25. The incubation period appears to be 12 weeks long. The symptoms include but are not limited to delirium, blurry vision (that can only be corrected by reading glasses), fascination with other people’s morbidity and mortality rates, and a desire to make the world a better place. Since the local county epidemiologist has succumbed to the disease, your services as a public health official have been requested. You are trying to create a case definition for this novel disease. What factors would you want to include to identify a Confirmed case in your case definition? Check all that apply.
Read DetailsPer our class discussion, Ro is a statistical value calculat…
Per our class discussion, Ro is a statistical value calculated using three main factors. 1. infectious period 2. Mode of Transmission 3. Contact Rate. Using the following example, choose which of these three factors the researchers observed in their study that impacted the Ro in the following analysis. (Choose all that apply) Despite highly successful vaccination programs and high vaccine uptake, both endemic pertussis and periodic pertussis outbreaks continue to occur. The under-recognized role of adolescents and adults in disease transmission, due to waning immunity following natural infection and vaccination, and reduced likelihood of correct diagnosis, may contribute to pertussis persistence. We constructed a mathematical model to describe the transmission of pertussis in both pre-vaccine and vaccine eras, to estimate the underlying burden of pertussis in the population. The model was well calibrated using the best available data on pertussis in the pre-vaccination (1880–1929) and vaccination (1993–2004) eras. Best-fit model estimates gave a basic reproductive number of approximately 10.6, (seasonal range 9.9 to 11.5). Under-reporting increased with age, and approximately >95% of infections in children were caused by infections in persons with waning immunity to pertussis following prior infection or vaccination. A well-calibrated model suggests that under-recognized cases of pertussis in older individuals are likely to be an important driver of ongoing pertussis outbreaks in children. Model projections strongly support the enhancement of booster vaccination efforts in adults. Pertussis Model ConstructionWe constructed an age-structured compartmental model that included births and deaths, and the introduction of the pertussis vaccine. Transmission of infection occurred through contact between susceptible or re-susceptible and infectious individuals. As individuals lost naturally-acquired or vaccine-induced immunity over time, they became re-susceptible to infection; we assumed that these individuals were equally susceptible as pertussis-naïve individuals, but were one-fifth as infectious (i.e., less likely to spread infection to others as assumed in previous models). This observed decrease in infectiousness incorporates both the hypothetical vaccine efficacy for infectiousness and the reduced duration of cough observed in partially immunized individuals.
Read DetailsIn response to the growing global burden of dengue fever, a…
In response to the growing global burden of dengue fever, a biotechnology company developed a new tetravalent dengue vaccine. Early phase clinical trials showed the vaccine was safe and generated an immune response. The company now seeks to evaluate whether the vaccine is effective at preventing symptomatic dengue infections in high-incidence areas. They enroll 10,000 healthy adult volunteers in Brazil, where dengue transmission is high. Participants are randomly assigned to receive either the dengue vaccine or a placebo. Over the next 18 months, participants are monitored for the development of laboratory-confirmed dengue infection. What type of study design is being conducted?
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