Upload an image of your drawings. About 30% of Thr in humans…
Upload an image of your drawings. About 30% of Thr in humans is degraded by the threonine dehydratase reaction. This reaction is parallel to the serine dehydratase reaction. The product of this Thr reaction is α – ketobutyrate (CH3CH2COCO2-). Write out the mechanism for this reaction.
Read DetailsMini case study: Alex is a 15-year-old Caucasian male, who i…
Mini case study: Alex is a 15-year-old Caucasian male, who is unable to perform strenuous exercise because he lacks the enzyme to effectively breakdown glycogen in the muscles. Alex’s blood was tested for alanine content. In a normal person, you would expect that blood alanine would increase during strenuous anaerobic exercise. But in Alex’s blood samples, there is a decrease in alanine concentration, leading you to believe that Alex’s muscle cells are taking up alanine rather than releasing it. Why would blood alanine concentrations increase in a normal person? (2 pts.) Hint: Think of the muscle fuel supply, the connection between pyruvate and alanine, and the role of nitrogen metabolism in the liver as well as, the liver’s role in gluconeogenesis. Why do blood alanine concentrations decrease in Alex? (2 pts.)
Read DetailsUpload an image of your drawing. Malate in the cytosol may b…
Upload an image of your drawing. Malate in the cytosol may be converted to pyruvate in a single step in a reaction catalyzed by malic enzyme. This reaction requires the cofactor NADP+ and is analogous to one of the reactions in the citric acid cycle This reaction along with the pentose phosphate pathway, provides reducing equivalents for fatty acid biosynthesis. Draw out this reaction showing the structures or names of the substrate, products and cofactors. Identify which step in the citric acid cycle that this reaction is most similar to.
Read DetailsUpload an image of your drawings. One of the intermediat…
Upload an image of your drawings. One of the intermediates in the biosynthesis of epinephrine is the amino acid L-dopa, which has two phenolic OH groups at the 3 and 4 positions of the benzene ring of Phe. Following the PLP mediated decarboxylation of L-dopa, the side chain alkyl group is hydroxylated to form the hormone norepinephrine. The final step in the biosynthesis of epinephrine is N-methylation of norepinephrine to form epinephrine by SAMe (S-adenosy methionine). Outline the series of reactions that would take a carbon atom from either Ser or Gly and deliver it as a methyl group to norepinephrine to form epinephrine. Show all necessary cofactors. You may use names, structures, or acceptable abbreviations. (4 pts.) Following the transfer of a methyl group, SAMe is converted to homocysteine. High levels of homocysteine in the blood have been correlated with coronary heart disease, stroke, atherosclerosis, neural tube defects, and dementia in the elderly. Homocysteine can react with Ser with the loss of water to form cystathionine. Cystathionine is cleaved to form Cys and α-ketobutyrate in a PLP dependent reaction. Show the series of reactions that converts
Read DetailsA 20-year-old man was stabbed in the chest with a jackknife…
A 20-year-old man was stabbed in the chest with a jackknife (pocket knife) with a blade five centimeters long. The stab wound in the left fourth intercostal space was approximately two centimeters lateral to the body of the sternum. What chamber of the heart would likely be injured?
Read DetailsAccording to new research, the AKAP11 gene was identified as…
According to new research, the AKAP11 gene was identified as a risk factor for what disease? (1 point) New research studying frogs have found that their claws evolved into what human trait? For an additional point, what gene family did it arise from? (2 points max) Why is the discovery of consistent DNA twisting by SMC proteins across different organisms significant from an evolutionary perspective? (2 points max) Select one biology topic that was covered in the course that you didn’t know about before (and surprised you). What was it? What did you learn and how will it affect you as you progress on your life journey? HAVE A FANTASTIC BREAK AND BEST OF LUCK IN YOUR FUTURE COURSES/CAREERS! Please take a few minutes and fill out the Course Survey that is in the newest Announcement; it helps me shape future classes.
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