Your female patient has colorectal cancer at age 55. Using…
Your female patient has colorectal cancer at age 55. Using the family history collected by the genetic counseling assistant you run a PREMM model (which includes your patient’s colorectal cancer and colorectal cancer in her paternal grandfather at age 60) and the risk of a pathogenic variant in a Lynch syndrome gene is estimated to be 2.1%. How does the finding that her tumor demonstrates absence of MSH2 and MSH6 change (or not) change your risk assessment?
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