The following is an excerpt from a recent scientific publication:“Amphetamine enters the presynaptic neuron … binds reversibly to TAAR1 or enters synaptic vesicles through VMAT2… When amphetamine reversibly binds to TAAR1, it reduces receptor firing rate … triggers signaling … result is transporter phosphorylation… transporters then operate in reverse…” What kind of interaction is primarily governing methamphetamine’s effects on transporter function?

A patient will be started on a continuous infusion of amiodarone at 0.5 mg/min. The nurse has 720 mg of amiodarone in a 500 mL bottle of D5W. What rate will the nurse program the infusion pump to deliver the amiodarone at 0.5 mg/min?

A salt bridge in a protein structure is best described as:

Which of the following species is the most nucleophilic in aqueous solution?

Which amino acid’s side chain can form a zwitterionic resonance-stabilized interaction in the active site of some enzymes?

Which type of interaction is least affected by the presence of water?

The hydrophobic effect is most important for stabilizing which level of protein structure?

The following is an excerpt from a recent scientific publication:“Because amino acid sequence determines protein structure and structure dictates biochemical function, proteins that share a similar amino acid sequence usually perform similar biochemical functions. Starting with the amino acid sequence of a protein, one can often predict which secondary structural elements… will be present in the protein. It is presently not possible, however, to deduce reliably the three-dimensional folded structure of a protein from its amino acid sequence unless its amino acid sequence is very similar to that of a protein whose three‑dimensional structure is already known. Additional information is required to understand the context in which the biochemical activity is used.” Which statement follows from the excerpt regarding prediction of protein function?

The following is an excerpt from a recent scientific publication:”…illustrating an internal H‑bond sampled between the piperidine and secondary amine nitrogen atoms… Internal H‑bond observed for the isolated compound becomes less likely in the presence of waters.” What inference can be made about oliceridine’s intramolecular hydrogen bonding in physiological (aqueous) environment?

Which of the following amino acids has a side chain that contains a thiol group?