In germinal centers, proliferating B cells undergo a process…
In germinal centers, proliferating B cells undergo a process called somatic hypermutation, in which mutations are introduced into the V regions of the antibody heavy and light chain genes. When this process is complete after several weeks, the overall affinities of the antibodies produced are greatly
Read DetailsEffector memory cells (TEM), are recirculating cells that c…
Effector memory cells (TEM), are recirculating cells that can readily enter tissues at sites of inflammation and are ready to rapidly respond to re-infection. The subset of TEM cells provides an important component of protective immunity to re-infection by the same pathogen because:
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