Baby Antoine was born in a remote part of Quebec, Canada. He…
Baby Antoine was born in a remote part of Quebec, Canada. He appeared to be a healthy six‐pound twelve‐ounce baby, except he did not eat well. During the weeks after his birth, he became more and more lethargic (sleepy, moving slowly), and he vomited periodically. His urine smelled of rotten cabbage. Baby Antoine gained only half a pound in six months and doctors had to feed him through a tube into his stomach. He gained weight and strength for a while, but died before he was a year old. It became apparent that other babies in the same area had similar symptoms, and people recalled similar deaths. Some families lost several children to Antoine’s disease. In those families, the parents were normal but about 25% of their children were affected. Specialists concluded that this was a genetic disorder. A. Based on the pedigree and information in the story above, is Antoine’s disease inherited as a dominant or a recessive trait? Explain your answer. B. What are the genotypes of these individuals? III‐J _________ II‐C _________ II‐D _________ C. If individual III-K married their first cousin III-S, what is the probability that they would produce an afflicted child? Show your work and/or calculations (when applicable).
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