A 78-year-old female patient has atrial fibrillation and hypertension. She requires treatment with rivaroxaban for stroke prophylaxis. You decide to check the patient’s renal function to decide on the correct dose. Her serum creatinine is found to be 126micromol/litre and her weight is 58kg. The following equation can be used to estimate creatinine clearance.     Constant: 1.04 (women); 1.23 (men) What is her estimated creatinine clearance? Give your answer to ONE (1) decimal place.

A patient has been prescribed oxaliplatin 130mg/m2 as an intravenous infusion. They have a body surface area of 1.55m2. How much oxaliplatin in milligrams will the patient receive during this infusion? Round your answer to the nearest 10mg.

You are a pharmacist working within a GP surgery. You are undertaking a project to switch all suitable patients from Asacol® 400mg MR tablets to Octasa® 400mg MR tablets. Asacol® 400mg MR tablets cost £27.45 for a 28 day supply and Octasa® 400mg MR tablets cost £15.70 for a 28 day supply. If you switch 50 patients from Asacol® to Octasa® 400mg MR tablets, what would be the 28-day cost saving in pounds (£)? Give your answer to the nearest pound.

Please explain, using the terminology we used in lecture, how a mutation causing loss of function in hypocretin receptors could disrupt normal sleep/wake cycles and be responsible for narcolepsy. Be sure to focus on molecular mechanisms and their relevance to the other sleep systems we discussed in class.

A testcross involves an individual with the dominant phenotype but unknown genotype being crossed with an individual that has a(n)________ genotype.

Approximately how many base pairs are still improperly matched in the bacterial genome after the DNA polymerase proofreads the DNA strand?

In what kind of classic Mendelian cross would you expect to find a ratio of 9:3:3:1 among the offspring?

The most likely time refers to the average time taken when an activity is repeated many times under the same conditions.

A project has an expected duration of 40 days and a standard deviation of 5 days. What is the Z-score for completing the project within 47 days?

A project has an expected duration of 84 days and a standard deviation of 6 days. What is the probability of completing the project within 90 days?