RULE OF 3s and 5s… Consider the antihistamine drugs Lorata…
RULE OF 3s and 5s… Consider the antihistamine drugs Loratadine (Claritin®) and Desloratadine (Clarinex®). Recall Lipinski’s Rule of 5 and answer the following questions… *** a) Does DESLORATADINE meet the requirements for hydrogen bond donor capability? How many HBD groups are present? [blank1] *** b) Does DESLORATADINE meet the requirement for hydrogen bond acceptor capability? How many HBA groups are present? [blank2] *** c) Is the in vivo metabolic conversion of loratadine to desloratadine a Phase I or II rxn? [blank3] *** d) Using the “RULE OF 3s”, complete the table below to predict whether the logP values for the drug DESLORATADINE would be less than, greater than, or equal to 0. Carbon# = [blank4] Water# = [blank5] Log P [blank6] 0
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