A microRNA (in red) binds to its mRNA target (black) as shown below:       Based on the degree of base-pairing observed, the target will NOT be cleaved.

An unusual gene from a Eukaryotic protozoan parasite that cause human diseases contains a “group I intron” that must be spliced out to form a mature mRNA that encodes a protein. If the entire exact DNA sequence (including the group I intron) for this gene is inserted into a prokaryote genome like E. coli, when E. coli tries to express this gene the resulting polypeptide sequence will be the same as when it is made in the parasite.

Which of the following codons in an mRNA can form a wobble-pair interaction with a tRNA that has an anticodon sequence of 5’-GAA-3’?

A DNA is observed to have a topology Lk=120. Which of the following topological configurations (Lk=Tw+wr) for that DNA molecule would require the action of a topoisomerase?

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Unusual vaginal bleeding (usually post-menopausal) is the most common sign/symptom of endometrial cancer.

All codons of an mRNA, including “STOP” codons, are recognized using Watson-Crick-Franklin base-pairing interactions with a corresponding tRNA.

Match the type of cancer to the correlating most common presenting sign/symptom.

For Translation, both Prokaryotes and Eukaryotes use base-pairing interactions with a sequence on mRNAs called the “Shine-Delgarno” to determine which start codon to initiate from.

For the Lac operon, a cell grown in “high lactose+no glucose” will have the same lac gene expression as a cell grown in “high lactose+ high glucose”.