What is the role of Protospacer Adjacent Motif (PAM) in the CRISPR/Cas9 system?

What is Mr A’s strongest risk factor for type 2 diabetes?

If Miss C’s hypothyroidism is not well controlled, what potential complication is she at risk of in pregnancy?

Which of the following are the most appropriate blood glucose targets for Mr A?   Waking Before meals 90 minutes after eating A 4-7 mmol/L 4-7 mmol/L 6-10 mmol/L B 5-7 mmol/L 4-7 mmol/L 5-9 mmol/L C 3-6 mmol/L 4-7 mmol/L 5-9 mmol/L D 4-7 mmol/L 5-9 mmol/L 5-9 mmol/L E 4-7 mmol/L 5-9 mmol/L 8-12 mmol/L  

Theme: Steroids Prednisolone can be stopped abruptly Prednisolone dose should be temporarily doubled Prednisolone dose should be temporarily halved Prednisolone dose should be tapered up slowly Prednisolone dose should be tapered down slowly Hydrocortisone IV should be given Hydrocortisone topical cream should be given Hydrocortisone oral tablets should be given   For each of the possible scenarios described in the following 3 questions, you have been asked to give advice with regards to steroid treatment. In these scenarios, Miss C is no longer pregnant or breastfeeding.  Select the most appropriate regimen from the options above. Each option may be used once, more than once or not at all.

At her recent antenatal appointment, the midwife discusses the topic of breastfeeding with Miss C. In addition to discussing health benefits for the baby, she also highlights potential health benefits to the breastfeeding mother. Breastfeeding lowers the risk of which of the following conditions for the mother?

Miss C is 16 weeks pregnant and has developed the following symptoms: urinary frequency, genital itching and whitish thick vaginal discharge. She attends her GP practice for assessment and a diagnosis of genital thrush (candida) is made. What would be the most appropriate treatment regimen for her? You may use the following resource: Candida – female genital | Health topics A to Z | CKS | NICE

A repeat eGFR of 51mL/min confirms a diagnosis of stage 3a chronic kidney disease. According to the SmPC, what is the most appropriate action to take in relation to canagliflozin prescribing? https://www.medicines.org.uk/emc/product/8855/smpc#gref 

Which of the following is the most appropriate advice to provide to Mr A with regards to his current medication if he experiences persistent diarrhoea or vomiting?

Are there any specific checks that should to be carried out following completion of gonorrhoea treatment?