Which of the following correctly describes the consequence of a mutation in PDK4 (pyruvate dehydrogenase kinase 4)?

Which of the following would occur in tumor cells treated with an mdm2 inhibitor?

Vincristine inhibits the “treadmilling” of which of the following cytoskeleton filaments:

Iron is required for ALL free radical production by doxorubicin.

Opening of the mitochondrial pore during necrosis causes which of the following?

Small molecule inhibitors that are currently used in veterinary oncology, e.g., Toceranib, target which of the following types of receptors?

A Collie comes in with lymphoma and the MDR1 status of the dog is not known. Which of the following chemotherapeutics should you use to start treatment while awaiting the MDR1 test results?

Growth factors stimulate the cell cycle during which of the following phases?

Alkylating agents such as cyclophosphamide or lomustine inhibit DNA replication by which of the following mechanisms?

Which of the following forms of cell death results in the release of internal cell constituents into the extracellular space thereby causing an inflammatory reaction?