The CBC for a patient shows decreased WBC and RBC values. Abnormal development is noted for a number of cells on the peripheral blood smear. A bone marrow is ordered and provides the following results: Cellularity is decreased, considering the age of the patient Normal M:E ratio Dysplastic changes noted in myelocytic and erythrocytic cell lines.  17% blasts; Auer rods present  

Interpret the following results: WBC count: 102 × 109/LDifferential: 13% segmented neutrophils28% band neutrophils15% metamyelocytes8% myelocytes6% promyelocytes15% lymphocytes8% basophils7% monocytes LAP score: 15 (reference interval:  0–400) What disease is suggested?

Neutrophils observed in the differential of a 14 year old boy demonstrate heavy purplish cytoplasmic granulation with the presence of dohle bodies. Chief complaint listed in the EMR is fever. This trait is indicative of

In a 1 month old with alpha thalassemia, you would expect to find:

What is the MCHC in grams per deciliter (g/dL)?

In hemoglobin C disease, how does the mutation affect the hemoglobin molecule?

A patient has the following CBC values WBC = 10.2 x 109/L RBC = 5.5 x 1012/L HGB = 11.3 g/dL HCT = 35.3 L/L MCH = 20 pg MCHC = 32.0 g/dL MCV = 64 fL PLTS = 222 x 109/L Using this data, calculate and interpret the mentzer index:    

A 25-year-old woman presents with fatigue and pallor. Her laboratory results are as follows: Hemoglobin (Hgb): 8.0 g/dL Hematocrit (Hct): 24% Reticulocyte Count: 5% RBC Count: 2.8 x 10⁶/µL Reticulocyte Maturation Factor: 2.0 (adjusted for anemia, for Hct

A patient’s hemoglobin electrophoresis on cellulose acetate shows a prominent band in the position of Hemoglobin S. However, the sickle solubility test is negative (image, middle). What is the most appropriate next step to confirm the identity of the hemoglobin variant?    

A 62-year-old patient presents with complaints of fatigue, pallor, and occasional shortness of breath. On examination, he has pale conjunctiva and mild glossitis. A CBC reveals the following results: Hemoglobin: 8.5 g/dL  MCV: 115 fL WBC: 3.2 x 10⁹/L  Platelets: 95 x 10⁹/L  Reflex Tests Ordered: Serum Vitamin B12: Low Serum Folate: Normal Serum Iron: Normal Bone Marrow Biopsy: Hypercellular with dysplasia in all three cell lines. Based on the clinical findings and laboratory results, which is the most likely diagnosis, and what features differentiate this diagnosis?