We talked about the regulation of gene expression and how it can happen at different steps.  Which of the following is an example of post-transcriptional (= after transcription!) control of gene expression?  (hint:  it’s really important in explaining the complexity found in Homo sapiens!!!)  

What dose should be administered 5.5 hours into the infusion (when the concentration is what you determined above) to bring the concentration to the steady-state level immediately?

If 275 mg was administered every 12 hours, predict the plasma concentration (mg/L) 4 hours after the second dose?

Why is it not possible to have a dosing interval greater than the taomax during an intermittent dosing regimen?

  As adults, we’re made up of trillions of cells and hundreds of different types of cells doing wildly different jobs in the body…. think how!  Muscle cells differ from nerve cells mainly because they ________.  

In the equation Cp,inf = Cpss*(1-e-KEt), the term (1-e-KEt) represents (Hint: what happens to the term when “t” increases)?

  CH14 vocabulary (part 1)… match the term to the correct definition (hint: copied primarily from quizlets!)  

  The genetic code is essentially the same for all organisms. From this, one can logically assume which of the following statements to be true? (hint: allows us humans to do some cool things in medicine… like producing insulin for diabetics)   

I have the following information for an infusion of Drug MJ2 Cp,1 hr = 0.160 mg/L Cp,5 hr = 0.721 mg/L Cp,10 hr = 1.72 mg/L Cp,ss = 3 mg/L Based on this information, determine the elimination rate constant of MJ2

While at steady-state during an infusion an increase in the volume of distribution of the infused drug